Asthma caused by tetracyclines


Occupations
  • Pharmaceutical industry
Agents
Tetracycline
 
Incidence
Incidence: only a few cases have been described.
 
The sensitization delay is always a few months.
 
Atopy does not play a role.
 
IgE-dependent mechanism.
 
Conditions
Only the parent tetracycline molecule seems to cause symptoms.
 
Symptoms
Classic asthma. There is a risk of anaphylactic reactions and reactivation of symptoms if the drug is taken orally.
 
Diagnostic methods
Skin tests: IDR from 10-5 fold dilution up to the neat product with a 15 minute period between each test.
 
Bronchial provocation tests have not been reported, but may be of interest.

References

  1. Clin. Allergy 1977, 7:285

As in all diagnostic testing, the diagnosis is made by the physican based on both test results and the patient history.