Asthma caused by macrolids


Occupations
  • Animal breeder
  • Doctor
  • Medical personnel
  • Pharmaceutical industry
  • Veterinary surgeon
 
Agents
Erythromycine, Oleandomycine, Spiramycine.
 
Incidence
Incidence: low.
 
No atopic predisposition.
 
IgE-dependent mechanism.
 
Macrolids are a class of reagents that act like haptens. Possibility of an antigenic cross reaction with lincomycin.
 
Conditions
Sensitization caused during the manufacture and handling of these chemical compounds.
 
Symptoms
Conjunctivitis, rhinitis and asthma. Contact eczema may also be encountered.
 
Diagnostic methods
Incidence: low.
 
No atopic predisposition.
 
IgE-dependent mechanism. 
 
Macrolids are a class of reagents that act like haptens. Possibility of an antigenic cross reaction with lincomycin.

References

  1. Contact Dermatitis 1980,6:410
  2. Thorax 1988 43:371
  3. Clin. Allergy 1979,9:571
  4. Clin. Allergy 1977,7:285
  5. Clin. Allergy 1975,5:99

As in all diagnostic testing, the diagnosis is made by the physican based on both test results and the patient history.