Asthma caused by aromatic amines and their derivatives

  • Dyeing industry
  • Furrier
  • Organic chemistry industry
  • Pharmaceutical industry
  • Rubber industry
1-5 Naphtylene diisocyanate, Paraphenylenediamine.

Incidence: very low incidence now. Asthmatic subjects are frequently atopic (IgE-dependent mechanism).
The hydroxyl, halide, nitro and sulphated derivatives are toxic. There is a danger of cancer of the bladder and methemoglobinemia.
Rhinitis and asthma associated with eczema may be present if the exposure to the risk has taken place over the long term.
Diagnostic methods
Bronchial provocation tests (in hospital) by inhalation: aqueous solution 3% as an aerosol.
Skin patch tests in the case of eczema. 


  1. J. Allergy, 1959,30:11
  2. J. Allergy, 1945,17:209

As in all diagnostic testing, the diagnosis is made by the physican based on both test results and the patient history.