Cynorhodon, Dog rose.
Incidence: probably low since only a few case have been reported and the vitamins industry is very large.
Cynorhodon is used in a spray form and therefore the risk is dose dependent.
Atopic subjects are more susceptible.
The ripe hip (fruit) of the dog rose going to seed after flowering is an important source of vitamin C and is used in the pharmaceutical and food industries.
Rhinitis and asthma. Urticaria and anaphylactic reactions have been reported.
Skin prick test: 0.1 and 1 mg/ml (not commercially available).
Immunological assay: ELISA (not commercially available).
Bronchial provocation test (in hospital) with an extract at 1/100 m/v.