Bet v 1 displays a considerable degree of heterogeneity and consists of at least 20 isoforms (Bet v 1a to Bet v 1n), which differ in their IgE-binding capacity (8,17,30,39). Although the major allergen Bet v 1 recognises serum-IgE antibodies in up to 95% of Birch pollen-allergic indivuals (30), studies among patients from 6 countries report highly variable IgE sensitisation profiles in Birch pollen-allergic patients from various countries and regions (40).
Bet v 2, a profilin, has been reported as being recognised by IgE from about 10% to 38% of Birch pollen-allergic patients from Central Europe (41-42.) The percentage affected clearly depends on the geographic area; in Swedish and Finnish patients, approximately 5-7% were sensitised to Birch profilin, compared to 20-38% of patients in Central and Southern Europe (42). Similarly, in a study that reported that few Finnish (2%) and Swedish (12%) patients had IgE to Bet v 2, Bet v 2 reactivity was found to be more common in the other populations (20% to 43%) (40).
Bet v 3 is recognised by IgE from about 10% of Birch allergic patients (30).
Bet v 4 reacts with serum IgE from approximately 20% of individuals allergic to pollen (8,19-20,30,43).
rBet v 5 bound IgE from 32% (9/28) sera from Birch pollen-allergic patients with an IgE antibody level of at least 3.50 kU/l (30).
Bet v 7, a cyclophilin, was recognised by IgE antibodies in up to 20.8% of Birch pollen-allergic patients (34).
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