Intense cross-reactivity exists among Italian funeral cypress tree, Arizona cypress tree and Mountain juniper tree, as well as other members of the Cupressaceae family (9-10).
Recombinant Cup a 1 (C. arizonica) has been shown to be highly homologous with the major allergens of Mountain cedar (Jun a 1), Japanese cypress (Cha o 1) and Japanese cedar (Cry j 1), confirming the cross-reactivity of conifer pollens (11-12). By inference, Italian funeral cypress tree pollen would share cross-reactivity with these allergens.
Cry j 2 may confer cross-allergenicity among Taxodiaceae and Cupressaceae (13).
Italian funeral cypress tree pollen has been shown to have common epitopes with Olive, Birch, Mugwort, Pine, and Cypress pollens (14).
Cross-reactivity has also been demonstrated among White cypress, Pine, Italian cypress, Rye grass, Birch, Cocksfoot, Couch grass, Lamb’s quarters, Wall pellitory, Olive, Plantain and Ragweed (15).
Podocarpus gracilior (Yellowood) and Callitris verrucosa contain allergens that cross-react with Italian funeral cypress tree pollen (16).
Complex glycan structures have been identified among the causes of the high degree of cross-reactivity between the Cupressaceae and Taxodiaceae families (17).
In a Spanish study examining sensitivity of patients with asthma and/or rhinoconjunctivitis to Cupressaceae pollen using skin prick tests, all the Cupressus-sensitive patients were found to be positive to Olea and Fraxinus, compared to 77% and 51% in the 2 Cupressus-negative groups (18).
Cross-reactivity between Italian funeral cypress pollen and Peach as a food has been reported in seven individuals. Symptoms of oral allergy syndrome, urticaria or angioedema occurred immediately following the ingestion of Peach: lip pruritus and oedema (n=3), urticaria (n=3) and angioedema (n=1). Italian funeral cypress pollen and Peach were shown to share a common allergen of 45 kDa (19).
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