ImmunoCAP Total IgE

Quantifying the total concentration of IgE with ImmunoCAP Total IgE results in the evaluation of IgE-mediated allergy

ImmunoCAP Total IgE is an in vitro test for quantitative measurement of the total amount of circulating IgE in human serum or plasma samples. IgE antibodies appear as a result of sensitization to allergens and measurement of circulating total IgE provides an aid in the clinical diagnosis of IgE-mediated allergic disorders. Elevated levels of circulating total IgE are usually seen in patients suffering from extrinsic asthma, hay fever or atopic eczema. 

Expected test values

The serum concentration of total IgE is age-related. It increases during childhood and, at about 10 years of age, serum total IgE reaches values that are maintained during adult life.

AgeGeometric
mean
(kU IgE/l)
+ 1 SD
(kU IgE/l)
AgeGeometric
mean
(kU IgE/l)
+ 1 SD
(kU IgE/l)
Weeks Years
 6  0.6  2.3  2  5.7  23
 Months  3  8.0  32
 3  1.0  4.1  4  10  40
 6  1.8  7.3  5  12  48
 9  2.6  10  6  14  56
 12  3.2  13  7  16  63
           8  18  71
 9  20  78
 10  22  85

Specimen collection and preparation

  • Serum and plasma (EDTA or heparin) samples from venous or capillary blood can be used
  • Collect blood samples using standard procedures
  • Keep specimens at room temperature (RT) for shipping purposes only
  • Store at 2–8 °C up to one week, otherwise store at –20 °C
  • Avoid repeated freezing and thawing

Important note

As in all diagnostic testing, a definitive clinical diagnosis should not be based solely on the results of a single test method. A diagnosis should be made by the physician after evaluation of all clinical and laboratory findings. 

Reference

Johansson S.G.O., Yman L. In Vitro Assays for Immunoglobulin E. Clin Rev Allergy 1988;6(2):93-139.

As in all diagnostic testing, the diagnosis is made by the physican based on both test results and the patient history.