Miscellaneous

Anti-IgA | Sperm Antibodies   

Anti-IgA

NEW!

Products

Article No.

No. of tests

EliA Anti-IgA 14-5535-01 2 x 12

 

Antigen

Purified human IgA

Promotion material

Flyer on EliA Anti-IgA (pdf)

Disease association and antibody prevalence

  • 40% of patients with selective IgA deficiency
  • 10 to 25% of patients with Common Variable Immunodeficiency (CVID)
Selective IgA deficiency is most common in celiac disease, while CVID is the most common symptomatic primary immunodeficiency (prevalence ~ 0.004 %) characterized by low serum levels of IgG, IgA and variably IgM.   

Prevent anaphylactoid reactions

Immunoglobulin G (IgG) replacement therapy represents an effective prophylaxis for infections in CVID patients. However, in any given IgG product, traces of IgA (0.05 to 6.0 mg/dl depending on the product) can be found. Therefore, patients with anti-IgA antibodies are at risk to develop an anaphylactoid reaction to these IgG formulations, especially upon intravenous andministration. The frequency of transufsion reactions is approximately 1 in 30,000 in the general population, while it is as high as up to 1 in 30 in IgA deficiency. 

When is the measurement recommended?

  1. Mandatory:
    Patients who have IgA deficiency and are destined for blood transfusion or IgG replacement therapy.
  2. Recommended:
    Celiac disease patients who are IgA deficient in order to assess a future risk for blood transfusions.
  3. Useful:
    Any IgA deficient patient in order to assess a future risk for blood transfusions.

Antibody isotype

IgG

References

Thon (2010)  |  Yuan S and Goldfinger D (2008)  |  Kumar V et al (2002)  |  Horn J et al (2006)  |  Lilic D and Sewell WAC (2008)  |  Brown R et al (2008  

Back to top    

  

Sperm Antibodies

Products

Article No.

No. of tests

Varelisa Sperm Antibodies 1 44 96 96

 

Antigen

Human sperm surface proteins purified 

 Back to top   

As in all diagnostic testing, the diagnosis is made by the physican based on both test results and the patient history.