The ISAC chip contains too many components from irrelevant sources for my patient? Why should I order ISAC in this case?
Answer: Results for other related components may also give useful information.
Example: For my patient some allergens on the ISAC-chip are irrelevant (e.g. birch pollen), while others relevant allergen, e.g. strawberry are not represented on ISAC.
Results: IgE abs to several allergens that belong to the PR-10 family are identified (birch Bet v 1 = 3 ISU, apple Mal d 1 = 7 ISU, kiwi Act d 8 = 45 ISU). How do I interpret these results given that birch pollen allergy is irrelevant for my patient?
Explanation: Even though specific markers for some allergens like strawberry may not be present on ISAC, cross-reacting allergens (such as profilins, PR-10 proteins, CCD or LTPs) originating from other sources may also be markers for strawberry. The IgE sensitizations have to come from some source, the primary/dominating allergen. It is often useful to study the entire IgE pattern to elucidate the original sensitizer “driving” the IgE pattern for closely related allergens. For example, strawberries contain components that belong to the PR-10 protein family, and in the above example the PR-10 proteins in strawberry may cause the clinical reactions to strawberry. The IgE levels also give useful information regarding the original/dominating sensitizer. In this example the PR-10 response is probably not birch pollen driven (only 3 ISU), instead kiwi (45 ISU) or strawberry may be the original sensitizer.
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