Why do we experience more flagged red spots with the new software MIA 1.1 and the ISAC 112 slides than with the ISAC 103 slides and the old software?

Why do we experience more flagged red spots with the new software MIA 1.1 and the 112 chip than with the 103 chip?
ISAC 112 has an improved chip quality, but more spots will be flagged by the new QC method. Users may take this as an indication of decreased ISAC quality, which is not the case. In MIA 3.12, one QC rule had to be fulfilled in order to flag a spot in red. Also, you didn’t need user approval to get the results from the chip. In MIA 1.1 and 1.2, one QC rule is enough to set the QC flag (red marker over spot). If 2 or 3 spots are QC flagged the user must manually set the spot to Good (G), Bad (B) or Negative (N).
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As in all diagnostic testing, the diagnosis is made by the physican based on both test results and the patient history.