Why do we see inhomogenous spot morphology (not perfectly round shaped, but more flowery)?

Why do we see inhomogenous spot morphology (not perfectly round shaped, but more flowery)
This is an effect that has been observed when the slides are not adapted to room temperature before opening the vacuum pack. The DfU states to allow the box to reach room temperature before opening the seal (Recommended: 15 minutes).
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As in all diagnostic testing, the diagnosis is made by the physican based on both test results and the patient history.