Do histone antibodies occur without other ANAs?

Do histone antibodies occur without other ANAs?

"Histone antibodies are amongst the most abundant in health and disease. They tend to arise with ageing and chronic infection, and as a response to therapy with various drugs. They may occur in rheumatoid arthritis and juvenile chronic arthritis. Titres are almost invariably high in drug induced lupus, and histone antibodies are particularly common in systemic lupus erythematosus and autoimmune chronic active (lupoid) hepatitis; they are probably responsible for the LE cell phenomenon." (Citation from Bernstein R, Autoantibody Manual C2.2, 1996).

Nevertheless, in our application lab in most cases histone antibodies are occurring together with anti-dsDNA antibodies (being positive in Varelisa, thus maybe low avidity dsDNA antibodies). Only in very rare cases we are finding a homogeneous pattern (HEp-2) in infections or healthy blood donors.

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As in all diagnostic testing, the diagnosis is made by the physican based on both test results and the patient history.