Are there patients with anti-streptavidin antibodies in their sera? And regarding streptavidin-coated tests: do unspecific reactions between these antibodies and the streptavidin influence the test results?

Are there patients with anti-streptavidin antibodies in their sera? And regarding streptavidin-coated tests: do unspecific reactions between these antibodies and the streptavidin influence the test results?

Yes there are patients with anti-streptavidin antibodies. And this also may be a reason for positive CTD-Screen test results but negative Symphony results.

Several tests are streptavidin-coated (CTD Screen, SmDp, Fib, Pm-Scl, Mi-2, PCNA, RNA Pol III, Scl-70s, PR3s, MPOs). Because the dilutions for this tests are always more than 1:10 (which means also an increased dilution of the streptavidin antibodies) there is in general no great influence, merely a slight increase of the results can be an implication of streptavidin antibodies.

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As in all diagnostic testing, the diagnosis is made by the physican based on both test results and the patient history.