In calprotectin assay, do we measure quantity of calprotectin released outside cells in stool - or calprotectin inside and outside the cells in stool?

In calprotectin assay, do we measure quantity of calprotectin released outside cells in stool - or calprotectin inside and outside the cells in stool?

Is this important? In stool there are certainly both intact and destroyed cells. Calprotectin occurs in stool because in intestinal inflammation granulocytes migrate through the intestinal wall into the intestinal lumen. There they may stay intact or may be destroyed. During stool extraction it may also happen that cells are destroyed. Thus, I would say that we certainly measure calprotectin level outside the cells, but it is derived from cell destruction, either by physiological processes or by extraction.

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As in all diagnostic testing, the diagnosis is made by the physican based on both test results and the patient history.