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Does the EliA beta 2-Glycoprotein include domain I of beta 2-Glycoprotein I? Is especially domain I of beta 2-Glycoprotein I a risk marker?

Do the EliA beta 2-Glycoprotein tests include domain I of beta 2-Glycoprotein I? Is especially domain I of beta 2-Glycoprotein I a new risk marker?

Yes, domain I of beta 2-Glycoprotein I (beta 2-GPI) is also included in our test, like all the other protein domains of this protein. For this tests we use human purified beta 2-GPI as antigen, so all the sufficient domains are comprised.

Inova advertised domain I as a risk marker for thrombosis and to a lesser extent for pregnancy complications in patients suffering from APS (Mahler M., Autoimmne Rev. 2012,  12(2):313-7). But the opinion of our KOL's is, that there is no sufficient sensitivity of domain I for use in routine diagnostics.

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Autoimmunity, Phospholipid Antibodies
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As in all diagnostic testing, the diagnosis is made by the physican based on both test results and the patient history.