Do the EliA beta 2-Glycoprotein tests include domain I of beta 2-Glycoprotein I? Is especially domain I of beta 2-Glycoprotein I a new risk marker?
Yes, domain I of beta 2-Glycoprotein I (beta 2-GPI) is also included in our test, like all the other protein domains of this protein. For this tests we use human purified beta 2-GPI as antigen, so all the sufficient domains are comprised.
Inova advertised domain I as a risk marker for thrombosis and to a lesser extent for pregnancy complications in patients suffering from APS (Mahler M., Autoimmne Rev. 2012, 12(2):313-7). But the opinion of our KOL's is, that there is no sufficient sensitivity of domain I for use in routine diagnostics.
This question is categorized under: