Do anti-CCP-antibodies occur in children?

Do anti-CCP-antibodies occur in children?

This is what we found in the literature

Rheumatoid Arthritis in children is an own disease and is called "juvenile rheumatoid arthritis"(JRA). Often the name "juvenile idiopathic arthritis"(JIA) is used for the same clinical picture.

Anti-CCP antibodies can be detected in some rare cases of JIA/JRA but almost exclusively in the subset of children with polyarticular disease and positive IgM rheumatoid factor.

These are the findings in different studies:

Authors
 

CCP in JIA/JRA

Comment

Source

Avcin T et al

2/109

 

Ann.Rheum.Dis. 2002; 61(7):608-611

Brunner J et al

2/45

Both polyarticular and RF+

Clin.Exp.Rheumatol. 2006; 24 (4):449-451

Ferucci ED

13/230

10/77 patients with polyarticular RF+, 3 of 139 pauciarticular

Arthritis Rheum. 2005; 52(1):239-246

Hromadnikova I et al

7/140

"no additional value of anti-CCP"

Autoimmunity 2002; 35 (6):397-401

Kasapcopur O et al

3/122

 

Ann.Rheum.Dis. 2004; 63 (12):1687-1689

Lee DM, Schur PH

6/21

Some of the JRA patients were adults (up to 31 yrs) with early onset

Ann.Rheum.Dis. 2003; 62:870-874

Syed RH et al

 17/72

 

Ann.Rheum.Dis. 2008; 67 (7):1049-1051

Van Rossum M et al

10/71

8 of 10 had polyarticular disease and were RF pos

J.Rheumatol. 2003; 30 (4):825-828

  
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As in all diagnostic testing, the diagnosis is made by the physican based on both test results and the patient history.